Fluorescence in situ hybridization sperm analysis of six translocation carriers provides evidence of an interchromosomal effect.

摘要: Objective To investigate the existence of an interchromosomal effect in balanced reciprocal translocation carriers and to evaluate their risk having affected child or repeated spontaneous abortions. Design Analysis chromosomal sperm content by fluorescence situ hybridization (FISH) using probes for chromosomes 1, 15, 16, 17, 18, X, Y. Setting University hospital. Patient(s) Six male chromosome rearrangements, one with normal parameters five oligoasthenoteratozoospermia, seven fertile controls. Intervention(s) Fluorescence enumeration on samples. Main Outcome Measure(s) Rate disomy studied chromosomes. Result(s) A total 123,842 spermatozoa were scored (82,181 controls 41,661 patients). For each patient, at least presented a significantly increased rate disomy. One patient showed clear three six studied. Disomy rates statistically inversely correlated progressive motility spermatozoa. Conclusion(s) The observed seems be translocation, dependent. Variable effects observed, according When we looked patients carrying same level was variable different