摘要: The general purpose of the thesis work is to improve astrochemical models in era ALMA. This characterized by active study protoplanetary disks and search for extraterrestrial life. First, we how uncertainties rate coefficients chemical reactions affect abundances column densities key molecules disks. We isolate a group species which have that are not very sensitive uncertainties, making them good potential tracers physical conditions identify about hundred with most problematic coefficients, need be determined more accurately order reliability modern models. Second, build realistic model using Monte Carlo approach all processes, first time this has been done. allows us properly take into account stochastic nature grain surface reactions, essential importance formation organic -- i.e., precursors life as know it. recent modified (MRE) Garrod et al. (2008) shown accurate fast accounting effects modeling. Finally, apply our composition an evolving disk growth, reveal process. For time, state-of-the-art coupled detailed growth sedimentation.