Copper(II) Complexes Based on Aminohydroxamic Acids: Synthesis, Structures, In Vitro Cytotoxicities and DNA/BSA Interactions
作者： Jia Zhang , Hua Yang , Dacheng Li , Jianmin Dou
DOI: 10.3390/CRYST8050201
关键词:
摘要: Four complexes, [Cu2(glyha)(bpy)2(H2O)]·2ClO4·H2O (1), [Cu2(glyha)(phen)2]·2ClO4 (2), [Cu2(alaha)(bpy)2Cl]·Cl·4H2O (3), and [{Cu2(alaha)(phen)2}{Cu2(alaha)(phen)2(NO3)}]·3NO3 (4) (glyha2− = dianion glycinehydroxamic acid, alaha2− alaninehydroxamic bpy 2,2′-bipyridine, phen 1,10-phenanthroline) have been successfully synthesized characterized by X-ray single crystal diffraction. The interactions of these complexes with calf thymus DNA (CT-DNA) were studied through UV spectroscopy, fluorescence circular dichroism. results revealed that 1–4 could interact CT-DNA intercalation. Interactions all bovine serum albumin (BSA) confirmed the docking study to quench intrinsic BSA in a static quenching process. Furthermore, vitro cytotoxic effect was also examined on four tumor cell lines, including human lung carcinoma line (A549), colon (HCT-116), promyelocytic leukemia (HL-60) cervical cancer (HeLa). All exhibited different antitumor activities.
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