Recombination and Molecular Epidemiology of HIV-1 and Enteroviruses

摘要: In addition to evolution by point mutations, many viruses have evolved mechanisms shuffle their genetic material between evolutionary lineages. Since only replicate as intracellular parasites, exchanges of materials require simultaneous infection a host and single cells with two or more lineages (i. e., strains). The exchange then takes place through the replication virus. case segmented genomes, for this are simple: simple mixing genome segments within cell results in random assortment packaging into progeny virions. It is believed that primary mechanism reassortment such Influenza A Rotavirus (Palese Young, 1982; Desselberger et al., 2001; Ramig Ward, 1991). For continuous segment physically link together genomes separate required produce recombinants. While ample evidence recombination exists viruses, understood few cases. Also, DNA- RNA-viruses probably recombine entirely different mechanisms.