Improved selection of patients for hepatic surgery of colorectal liver metastases with (18)F-FDG PET: a randomized study

摘要: With the increasing possibilities for surgical treatment of colorectal liver metastases, careful selection patients who may benefit from becomes critical. The addition PET to (18)F-FDG significantly improve conventional staging by CT. Up now, definitive evidence that leads superior clinical results and improved management in these has been lacking. In this randomized controlled trial with we investigated whether is beneficial reduces number futile laparotomies. METHODS: A total 150 metastases selected imaging CT were randomly assigned only (n = 75) or plus 75). Patients followed up at least 3 y. primary outcome measure was laparotomy, defined as any laparotomy did not result complete tumor treatment, revealed benign disease, a disease-free survival period longer than 6 mo. RESULTS: Patient characteristics similar both groups. laparotomies 34 (45%) control arm without 21 (28%) experimental PET; relative risk reduction 38% (95% confidence interval, 4%-60%, P 0.042). CONCLUSION: reduced 45% 28%; thus, work-up resection prevents unnecessary surgery 1 patients.