Does mercury from amalgam restorations constitute a health hazard

作者: Jan A. Weiner , Magnus Nylander , Fredrik Berglund

DOI: 10.1016/0048-9697(90)90206-A

关键词:

摘要: Amalgam is the most extensively used implant material in dentistry. There have been no clinical trials of this substance and there are epidemiological studies that allow any conclusions on safety amalgam fillings. restorations continuously emit mercury vapour, which absorbed considerable quantities via lungs. A comparison with dose-effect relationships, obtained occupational studies, for certain effects kidneys central nervous system (CNS), suggests individuals unusually high emission from fillings at risk. It unclear whether or not clinically significant could be expected. The limited sensitivity available together insufficient knowledge possible host factors affecting resistance to mercury, implies other more severe susceptible cannot excluded. Information long-term organs than brain kidney sparse. Animal suggest possibility immune reactions i.e. development autoimmunity, primarily dose-dependent, but rather depend genetic susceptibility. From a toxicological point view, an unsuitable dental restorations.

参考文章(132)
Thomas W. Clarkson, Lars Friberg, John B. Hursh, Magnus Nylander, The Prediction Of Intake Of Mercury Vapor from Amalgams Biological Monitoring of Toxic Metals. pp. 247- 264 ,(1988) , 10.1007/978-1-4613-0961-1_9
Milikan Lj, Cutright De, Miller Ra, Battistone Gc, Systemic mercury levels caused by inhaling mist during high-speed amalgam grinding. Journal of oral medicine. ,vol. 28, pp. 100- 104 ,(1973)
Gerhard Triebig, Thomas Grobe, Erika Saure, Karl-Heinz Schaller, Dieter Weltle, Helmut Valentin, Untersuchungen zur neurotoxizit�t von arbeitsstoffen International Archives of Occupational and Environmental Health. ,vol. 55, pp. 19- 31 ,(1984) , 10.1007/BF00378064
Hernberg S, "Negative" results in cohort studies--how to recognize fallacies. Scandinavian Journal of Work, Environment & Health. ,vol. 7, pp. 121- 126 ,(1981)
Björkman L, Friberg L, Eggleston D, Nylander M, Mercury accumulation in tissues from dental staff and controls in relation to exposure. Swedish Dental Journal. ,vol. 13, pp. 235- 243 ,(1989)
Vizena Tr, Lovejoy Hb, Bell Zg, Mercury exposure evaluations and their correlation with urine mercury excretions. 4. Elimination of mercury by sweating. Journal of Occupational and Environmental Medicine. ,vol. 15, pp. 590- ,(1973)
J. Contrino, P. Marucha, D. L. Kreutzer, R. Ribaudo, R. Ference, P. E. Bigazzi, Effects of mercury on human polymorphonuclear leukocyte function in vitro. American Journal of Pathology. ,vol. 132, pp. 110- 118 ,(1988)
David A. Lawrence, Heavy metal modulation of lymphocyte activities Toxicology and Applied Pharmacology. ,vol. 57, pp. 439- 451 ,(1981) , 10.1016/0041-008X(81)90241-6
Maths Berlin, Sven Ullberg, Accumulation and Retention of Mercury in the Mouse Archives of Environmental Health: An International Journal. ,vol. 6, pp. 589- 601 ,(1963) , 10.1080/00039896.1963.10663447
Eugene William Skinner, The science of dental materials Saunders. ,(1940)