AP-3-dependent trafficking and disease: the first decade

摘要: The adaptor protein (AP)-3 complex defines a pathway for the intracellular trafficking of membrane-associated proteins in most eukaryotic cells. Ten years ago, genetic defects AP-3 were linked to human Mendelian disease, named Hermansky–Pudlak syndrome, characterized by abnormal biogenesis and function lysosome-related organelles such as melanosomes platelet dense granules. During recent years, research on this has significantly expanded its horizons include evolutionarily divergent models embrace functional genomics proteomics approaches. These studies have brought into focus ideas about specific roles organelle within endosomal–lysosomal system.