Trends in incidence of hepatocellular carcinoma after diagnosis of hepatitis B or C infection: a population-based cohort study, 1992-2007.

摘要: Summary.  Chronic hepatitis B virus (HBV) and C (HCV) infections are the major risk factors for hepatocellular carcinoma (HCC). We examined trends in incidence of HCC among a population-based cohort people infected with HBV or HCV. HCV cases notified to New South Wales Health Department between 1992 2007 were linked Central Cancer Registry, Registry Births, Deaths Marriages, National HIV/AIDS Registries. Crude rates estimated using person-time methodology. Age-standardized calculated 2001 Australian population. Trends join point regression models. Between 2007, 1201 had record: 556 those HBV; 592 HCV; 45 HBV/HCV co-infection; 8 HIV co-infection. The overall age-standardized declined non-significantly from 148.0 (95% confidence intervals (CI) 63.7, 287.4) per 100 000 population 1995 101.2 CI 67.3, 144.6) monoinfected group significantly 151.8 62.4, 299.8) 75.3 50.8, 105.5) group. However, progressively increased period 1992–1997 2004–2007 when adjusted age, sex, birth cohort, total number annum continued increase. Despite declines age-adjusted over time, absolute likely due ageing an increasing prevalence both Australia.