Carbon dioxide fixation in the brain.

摘要: SUMMARY Carbon dioxide fixation in brain was studied cats to which NaHVO+ with and without ammonia, administered by intracarotid infusion. Glutamic aspartic acids, glutamine, glutathione, y-aminobutyric acid were isolated from blood, brain, liver, their specific activities determined. The data indicate a significant incorporation of CO2 into the amino acids cerebral cortex, presumably way citric cycle. Without simultaneous ammonia infusion, activity is 3 times that whereas presence ratios both compounds are closer unity or reversed. suggest oxaloacetic channeled glutamine formation. y-Aminobutyric iso- lated tissue, as well obtained after decarboxyla- tion glutamic has less than 5% counts precursor. These findings give additional support assumption operation mech- anism similar liver. Additional on compartmentation synthesis presented.