Influence of nature of side chain on conformation of alternatingl- andd-stereo oligopeptides
作者： Shantaram Kamath , Evans Coutinho
DOI: 10.1007/BF02872600
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摘要: Peptides containing residues with alternatingd- andl-stereochemistry in the backbone have been studied for their single-strand helix-forming capability by molecular dynamics (MD) simulations. The influence of nature side chain such as steric, branching and polarity on helix forming ability has probed studyingt-Boc-(l-Ala-d-Ala)4-OMe (small hydrophobic chain),t-Boc-(l-Phe-d-Phe)4-OMe (bulky chain),t-Boc-(l-Val-d-Val)4-OMe (β-branch chain),t-Boc-(d-allolle-l-Ile)3-OMe (γ-branch chain), andt-Boc-(l-Ala-d-Ser)4-OMe (hydrophobic hydrophilic chains). Besides this, effect unsymmetricalα,α-disubstitution Cα carbons stability also investigated. results show that peptides, exception those withα,α-disubstitution, a unique to formβ-helices.
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sci-hub.se 参考文章(16)
F. Colonna-Cesari, S. Premilat, F. Heitz, G. Spach, B. Lotz, Helical structures of poly(D-L-peptides). A conformational energy analysis. Macromolecules. ,vol. 10, pp. 1284- 1288 ,(1977) , 10.1021/MA60060A023
P. De Santis, S. Morosetti, R. Rizzo, Conformational Analysis of Regular Enantiomeric Sequences Macromolecules. ,vol. 7, pp. 52- 58 ,(1974) , 10.1021/MA60037A011
B. Lotz, F. Colonna-Cesari, F. Heitz, G. Spach, A family of double helices of alternating poly(γ-benzyl-d-l-glutamate), a stereochemical model for gramicidin A Journal of Molecular Biology. ,vol. 106, pp. 915- 942 ,(1976) , 10.1016/0022-2836(76)90343-0
D. W. Urry, M. C. Goodall, J. D. Glickson, D. F. Mayers, The Gramicidin A Transmembrane Channel: Characteristics of Head-to-Head Dimerized π(L,D) Helices Proceedings of the National Academy of Sciences of the United States of America. ,vol. 68, pp. 1907- 1911 ,(1971) , 10.1073/PNAS.68.8.1907
F. Heitz, B. Lotz, G. Spach, αDL and πDL Helices of alternating poly-γ-benzyl-d-l-glutamate Journal of Molecular Biology. ,vol. 92, pp. 1- 13 ,(1975) , 10.1016/0022-2836(75)90088-1
J.R. Berendsen, H.J.C., Postma, J.P.M., Van Gunsteren, W.F., Dinola, A., Haak, Molecular dynamics with coupling to an external bath Journal of Chemical Physics. ,vol. 81, pp. 3684- 3690 ,(1984) , 10.1063/1.448118
F. Theodore Hesselink, Harold A. Scheraga, On the Possible Existence of α-Helical Structures of Regular-Sequence D,L Copolymers of Amino Acids. Conformational Energy Calculations Macromolecules. ,vol. 5, pp. 455- 463 ,(1972) , 10.1021/MA60028A022
P. M. Hardy, J. C. Haylock, D. I. Marlborough, H. N. Rydon, H. T. Storey, R. C. Thompson, Conformations of "Alternating" Sequential Polypeptides in Solution Macromolecules. ,vol. 4, pp. 435- 440 ,(1971) , 10.1021/MA60022A013
D. W. Urry, A Molecular Theory of Ion-Conducting Channels: A Field-Dependent Transition Between Conducting and Nonconducting Conformations Proceedings of the National Academy of Sciences of the United States of America. ,vol. 69, pp. 1610- 1614 ,(1972) , 10.1073/PNAS.69.6.1610
Gian Paolo Lorenzi, Lera Tomasic, .beta. Helices formed in cyclohexane solution by oligomeric chains of alternating L- and D-valine residues. Relationship between sequence and prevailing helical sense Journal of the American Chemical Society. ,vol. 99, pp. 8322- 8323 ,(1977) , 10.1021/JA00467A037