Eosinophilic leukaemias and the idiopathic hypereosinophilic syndrome.

摘要: Hypereosinophilic syndromes may result either from eosinophilic differentiation of a clone neoplastic cells or reactive eosinophilia. In other patients HES is idiopathic. It appears likely that in many the "idiopathic' hypereosinophilic syndrome actually chronic myeloproliferative disorder. Those cases showing an increase blast demonstrable clonal cytogenetic abnormality should be classified as leukaemia. nature disease can recognized only retrospect when granulocytic sarcoma AMI, develops. A few idiopathic are consequent on cytokine secretion whereas others remain at time death. When eosinophilia occurs feature acute myeloid leukaemia disorder eosinophils usually part leukaemic clone. However, association with lymphoblastic reactive. Rare have biphenotypic leukaemia/lymphoma both and lymphoid arising mutant pluripotent stem cell.