Physiological, metabolic and transcriptional postnatal phenotypes of in vitro fertilization (IVF) in the mouse.
作者： S. K. Feuer , P. F. Rinaudo
DOI: 10.1017/S204017441700023X
关键词:
摘要: Approximately 1-4% of children today are conceived using assisted reproductive technologies (ARTs), including in vitro fertilization (IVF). IVF is considered safe and the great majority these healthy, yet there increasing physiological molecular evidence from animal models that ART associated with postnatal metabolic cardiovascular alterations. Understanding mechanisms underlying changes determining whether they have biological significance paramount importance for optimizing design culture conditions improving health across life course. In this review, we examine present adult tissues rodent offspring generated by preimplantation manipulation gametes embryos. Although embryo can induce common transcriptional effects blastocyst, metabolomic signatures largely tissue-specific. However, pervasive oxidative stress dysfunction, indicating a lasting effect on physiology.
sci-hub.se 参考文章(61)
Steffen Biechele, Chih-Jen Lin, Paolo F Rinaudo, Miguel Ramalho-Santos, Unwind and transcribe: chromatin reprogramming in the early mammalian embryo Current Opinion in Genetics & Development. ,vol. 34, pp. 17- 23 ,(2015) , 10.1016/J.GDE.2015.06.003
ELISA CEBRAL, ISABEL CARRASCO, DAVID VANTMAN, ROSITA SMITH, Preimplantation embryotoxicity after mouse embryo exposition to reactive oxygen species. Biocell. ,vol. 31, pp. 51- 59 ,(2007) , 10.32604/BIOCELL.2007.31.051
R. K. Simbulan, X. Liu, S. K. Feuer, E. Maltepe, A. Donjacour, P. Rinaudo, Adult male mice conceived by in vitro fertilization exhibit increased glucocorticoid receptor expression in fat tissue. Journal of Developmental Origins of Health and Disease. ,vol. 7, pp. 73- 82 ,(2016) , 10.1017/S2040174415007825
K. Servick, Unsettled questions trail IVF's success. Science. ,vol. 345, pp. 744- 746 ,(2014) , 10.1126/SCIENCE.345.6198.744
S. T. Y. Hui, A. M. Andres, A. K. Miller, N. J. Spann, D. W. Potter, N. M. Post, A. Z. Chen, S. Sachithanantham, D. Y. Jung, J. K. Kim, R. A. Davis, Txnip balances metabolic and growth signaling via PTEN disulfide reduction Proceedings of the National Academy of Sciences of the United States of America. ,vol. 105, pp. 3921- 3926 ,(2008) , 10.1073/PNAS.0800293105
Elpiniki Chronopoulou, Joyce C. Harper, IVF culture media: past, present and future Human Reproduction Update. ,vol. 21, pp. 39- 55 ,(2015) , 10.1093/HUMUPD/DMU040
Vincent W. V. Jaddoe, Jacqueline C. M. Witteman, Hypotheses on the fetal origins of adult diseases: contributions of epidemiological studies. European Journal of Epidemiology. ,vol. 21, pp. 91- 102 ,(2006) , 10.1007/S10654-005-5924-5
Gnanaratnam Giritharan, Said Talbi, Annemarie Donjacour, Francesca Di Sebastiano, Anthony T Dobson, Paolo F Rinaudo, Effect of in vitro fertilization on gene expression and development of mouse preimplantation embryos Reproduction. ,vol. 134, pp. 63- 72 ,(2007) , 10.1530/REP-06-0247
Jie Zhou, Hong Liu, Hai-tao Gu, Yu-gui Cui, Nan-nan Zhao, Juan Chen, Li Gao, Yuan Zhang, Jia-yin Liu, None, Association of cardiac development with assisted reproductive technology in childhood: a prospective single-blind pilot study. Cellular Physiology and Biochemistry. ,vol. 34, pp. 988- 1000 ,(2014) , 10.1159/000366315
Tiangang Li, Jessica M. Francl, Shannon Boehme, Adrian Ochoa, Youcai Zhang, Curtis D. Klaassen, Sandra K. Erickson, John Y. L. Chiang, Glucose and Insulin Induction of Bile Acid Synthesis MECHANISMS AND IMPLICATION IN DIABETES AND OBESITY Journal of Biological Chemistry. ,vol. 287, pp. 1861- 1873 ,(2012) , 10.1074/JBC.M111.305789