Anti-microbial biotherapeutic agents: alternatives to conventional pharmaceutical antibiotics

摘要: Novel antimicrobial agents that can serve as replacements to conventional pharmaceutical antibiotics are disclosed. The comprise conjugatively transmissible plasmids kill targeted pathogenic bacteria, but not harmful donor bacteria. Two types of lethal One type kills recipient bacteria by unchecked (“runaway”) replication in the cells and is prevented from occurring cells. Another expressing a gene produces product detrimental or bacterial cells, being expression