Production of thermoreversible hydrogels for therapeutic applications
作者： Uri Shpolansky , Marina Konorty , Yosh Dollberg , Gil Hakim , Nadav Malchi
DOI:
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摘要: A method is disclosed for production of a sterile thermoreversible hydrogel characterized by known temperature T min at which the viscosity reaches least local minimum. In preferred embodiment invention, comprises dissolving components in water within ±4° C. ; forming hydrogel; and filtering . The final sterilization can be obtained under aseptic conditions or autoclaving irradiation product. other embodiments, gel are dissolved sufficiently large quantity that reduces precludes formation hydrogel, sufficient then removed vacuum to produce hydrogel.
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