Feline CTLA-4 nucleic acid and polypeptides

作者: Ellen W. Collisson , Insoo Choi , Barbara J. Winslow , Mark D. Cochran

DOI:

关键词:

摘要: The present invention provides isolated and purified DNA encoding feline CD80 (B7-1) ligand, CD86 (B7-2) CD28 receptor, or CTLA-4 (CD152) as well vectors comprising nucleic acid CD80, CD86, CD28, CTLA-4. a host cells transformed with CD80-encoding vectors, CD86-encoding CD28-encoding CTLA-4-encoding vectors. polypeptides encoded by the of vaccine an effective amount also vaccines which further comprise immunogens derived from pathogens. for capable enhancing immune response. suppressing

参考文章(163)
Saukkonen Jj, Kornfeld H, Berman Js, Expansion of a CD8+CD28- cell population in the blood and lung of HIV-positive patients. Journal of Acquired Immune Deficiency Syndromes. ,vol. 6, pp. 1194- 1204 ,(1993)
B. J. Nickoloff, L. A. Turka, R. S. Mitra, Yoji Shimizu, C. Thompson, J. Green, K. Lee, Discordant expression of CD28 ligands, BB-1, and B7 on keratinocytes in vitro and psoriatic cells in vivo. American Journal of Pathology. ,vol. 142, pp. 1029- 1040 ,(1993)
Shumin Yang, Karen S. Sellins, Gek-Kee Sim, T cell costimulatory proteins, sequences and uses thereof ,(1999)
Marc Jenkins, S. D. Norton, K. B. Urdahl, P. S. Taylor, CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells. Journal of Immunology. ,vol. 147, pp. 2461- 2466 ,(1991)
Peter S. Linsley, Laurence A. Turka, Gary L. Schieven, Robert Paine, Craig B. Thompson, Jeffrey A. Ledbetter, Signal transduction via CD4, CD8, and CD28 in mature and immature thymocytes. Implications for thymic selection. Journal of Immunology. ,vol. 146, pp. 1428- 1436 ,(1991)
Alan M. Krensky, Rosemarie DeKruyff, Carol Clayberger, Peter Parham, Shu Chen Lyu, Peptides corresponding to the CD8 and CD4 binding domains of HLA molecules block T lymphocyte immune responses in vitro. Journal of Immunology. ,vol. 153, pp. 946- 951 ,(1994)
L L Lanier, S O'Fallon, M Azuma, J H Phillips, K Okumura, P S Linsley, D Ito, C Somoza, CD80 (B7) and CD86 (B70) provide similar costimulatory signals for T cell proliferation, cytokine production, and generation of CTL. Journal of Immunology. ,vol. 154, pp. 97- 105 ,(1995)
T R Mosmann, T A Fong, Alloreactive murine CD8+ T cell clones secrete the Th1 pattern of cytokines. Journal of Immunology. ,vol. 144, pp. 1744- 1752 ,(1990)
P. S. Linsley, R. N. Germain, L. Ding, E. M. Shevach, Li-Yun Huang, IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. Journal of Immunology. ,vol. 151, pp. 1224- 1234 ,(1993)
Peter S. Linsley, Alejandro Aruffo, Gina Leytze, Nitin K. Damle, Kerry Klussman, Sigrid Myrdal, Jeffrey A. Ledbetter, Costimulation of T lymphocytes with integrin ligands intercellular adhesion molecule-1 or vascular cell adhesion molecule-1 induces functional expression of CTLA-4, a second receptor for B7. Journal of Immunology. ,vol. 152, pp. 2686- 2697 ,(1994)