Brief report: treatment of severe colchicine overdose with colchicine-specific Fab fragments.
作者： Frédéric J. Baud , Alain Sabouraud , Eric Vicaut , Pierre Taboulet , Jean Lang
DOI: 10.1056/NEJM199503093321004
关键词:
摘要: The use of colchicine is limited by its toxicity,1 and overdose associated with a high mortality rate. Patients early hemodynamic collapse due to have particularly poor prognoses,2,3 there has been no effective treatment for this complication severe intoxication.4 Colchicine binds reversibly tubulin,5 colchicine-specific antibodies shown restore the activity tubulin in vitro.6,7 Colchicine-specific active immunization rabbits passive mice substoichiometric doses goat their Fab fragments prevent or reverse acute poisoning.8–11 These . . .
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