Role of Glutathione in the Aging and Development of Insects

作者: R. G. Allen , R. S. Sohal

DOI: 10.1007/978-3-642-70853-4_13

关键词:

摘要: Glutathione is a tripeptide consisting of glutamic acid, cysteine and glycine moieties, found in all aerobes (Kosower Kosower 1976). may exist the reduced form (GSH) or as an oxidized dimer (GSSG). More than 90% glutathione contained cells GSH; form, GSSG, rapidly to GSH by reductase extruded from (Meister Anderson 1983). The cellular concentration usually high, exceeding one millimolar many tissues plays important role multiple physiological processes, due mainly its ability donate reducing equivalents; indeed, most equivalents are (Chance et al. 1979). Although principle detoxify potentially deleterious substances, including oxygen free radicals, it strongly modulates redox state cells, which function ratio oxidizing

参考文章(59)
R. S. Sohal, R. G. Allen, Relationship between Metabolic Rate, Free Radicals, Differentiation and Aging: A Unified Theory Molecular Biology of Aging. ,vol. 35, pp. 75- 104 ,(1985) , 10.1007/978-1-4899-2218-2_4
K Nishiki, D Jamieson, N Oshino, B Chance, Oxygen toxicity in the perfused rat liver and lung under hyperbaric conditions. Biochemical Journal. ,vol. 160, pp. 343- 355 ,(1976) , 10.1042/BJ1600343
R. S. Sohal, Donald Armstrong, Richard G. Cutler, Free Radicals in Molecular Biology, Aging, and Disease ,(1984)
György Lustyik, György Balázs, Géza Lukács, Valéria Zs.-Nagy, Imre Zs.-Nagy, Correlation of malignancy with the intracellular Na+:K+ ratio in human thyroid tumors. Cancer Research. ,vol. 43, pp. 5395- 5402 ,(1983)
Robert S. Horn, Niels Haugaard, Inhibition of Carbohydrate Metabolism by Oxygen and N-Ethylmaleimide in Rat Heart Homogenates Journal of Biological Chemistry. ,vol. 241, pp. 3078- 3082 ,(1966) , 10.1016/S0021-9258(18)96500-2
Michael Ashburner, Patterns of puffing activity in the salivary gland chromosomes of Drosophila Chromosoma. ,vol. 27, pp. 156- 177 ,(1969) , 10.1007/BF00326142
T Kuroki, R Montesano, C Drevon, L St Vincent, T D Pugh, S Goldfarb, E Huberman, gamma-Glutamyl transpeptidase and malignant transformation of cultured liver cells. Cancer Research. ,vol. 39, pp. 269- 272 ,(1979)
Byeong-Kuk Seon, Oliver A. Roholt, David Pressman, Differences in the Enzymatic Digestibility of the Variable and Constant Halves of Bence-Jones Protein with Temperature Journal of Biological Chemistry. ,vol. 247, pp. 2151- 2155 ,(1972) , 10.1016/S0021-9258(19)45504-X