A Precise Circadian Clock from Chaotic Cell Cycle Oscillations

摘要: In this chapter I attempt to set out in detail the background, experimental results and computer simulations that have led idea timing of cell division, scheduling events within cycle, as well many exquisitely precise functions circadian rhythms, are all expressions a fundamental macromolecular ultradian oscillator. A novel component argument is underlying oscillator not periodic, limit cycle oscillator, commonly supposed, but strange, or chaotic attractor. This view consistent with long-recognized truth oscillations cellular constituents seen isolated eukaryotic cells rarely impressive statistically. show that, when large numbers brought together caused share some one oscillating components, periodicity frequent result. The two outcomes interest biological self-organization, periodic spiral waves synchronization, emerge from interaction fields attractors coupled by diffusion. Self-organization structures imprecise components appears require early establishment an antipodal phase relationship between few near core spiral.