Expression of ASAP1 and FAK in gastric cancer and its clinicopathological significance.
作者： Qiong Luo , Suyun Zhang , Donghuan Zhang , Fang Yuan , Xiangqi Chen
关键词:
摘要: The present study aimed to analyze the expression levels of adenosine diphosphate ribosylation factor guanylate kinase 1 (ASAP1) and focal adhesion (FAK) in gastric cancer (GC) tissues order explore their association with clinicopathological features prognosis. A total 32 patients GC were enrolled study. All had complete clinical follow-up data paraffin-embedded normal mucosal tissues. ASAP1 FAK these measured by immunohistochemistry. associations factors survival subsequently analyzed. (59.4%) (68.8%) significantly higher than those (28.1 40.6%, P<0.05). associated depth invasion, lymph node metastasis pathological stage (P<0.05). was positively (P<0.001). In addition, negatively disease-free time overall 5-year rate negative or compared that positive conclusion, highly expressed human may serve a synergistic role promoting tumorigenesis, progression, invasion GC. patient's survival. Therefore, represent novel molecular markers for pathophysiology prognosis
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Aitziber Buqué, Norma Bloy, Fernando Aranda, Francesca Castoldi, Alexander Eggermont, Isabelle Cremer, Wolf Hervé Fridman, Jitka Fucikova, Jérôme Galon, Aurélien Marabelle, Radek Spisek, Eric Tartour, Laurence Zitvogel, Guido Kroemer, Lorenzo Galluzzi, Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications OncoImmunology. ,vol. 4, ,(2017) , 10.1080/2162402X.2015.1008814
Jacques Ferlay, Isabelle Soerjomataram, Rajesh Dikshit, Sultan Eser, Colin Mathers, Marise Rebelo, Donald Maxwell Parkin, David Forman, Freddie Bray, Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer. ,vol. 136, ,(2015) , 10.1002/IJC.29210
Nicholas J. Petrelli, Eric P. Winer, Julie Brahmer, Sarita Dubey, Sonali Smith, Charles Thomas, Linda T. Vahdat, Jennifer Obel, Nicholas Vogelzang, Maurie Markman, John W. Sweetenham, David Pfister, Mark G. Kris, Lynn M. Schuchter, Raymond Sawaya, Derek Raghavan, Patricia A. Ganz, Barnett Kramer, Clinical cancer advances 2009: Major research advances in cancer treatment, prevention, and screening -A report from the American Society of Clinical Oncology Journal of Clinical Oncology. ,vol. 27, pp. 6052- 6069 ,(2009) , 10.1200/JCO.2009.26.6171
T Miyazaki, H Kato, M Nakajima, M Sohda, Y Fukai, N Masuda, R Manda, M Fukuchi, K Tsukada, H Kuwano, FAK overexpression is correlated with tumour invasiveness and lymph node metastasis in oesophageal squamous cell carcinoma. British Journal of Cancer. ,vol. 89, pp. 140- 145 ,(2003) , 10.1038/SJ.BJC.6601050
Yunhao Liu, Gil M. Yerushalmi, Pablo R. Grigera, J. Thomas Parsons, Mislocalization or Reduced Expression of Arf GTPase-activating Protein ASAP1 Inhibits Cell Spreading and Migration by Influencing Arf1 GTPase Cycling Journal of Biological Chemistry. ,vol. 280, pp. 8884- 8892 ,(2005) , 10.1074/JBC.M412200200
K. Brami-Cherrier, N. Gervasi, D. Arsenieva, K. Walkiewicz, M.-C. Boutterin, A. Ortega, P. G. Leonard, B. Seantier, L. Gasmi, T. Bouceba, G. Kadare, J.-A. Girault, S. T. Arold, FAK dimerization controls its kinase‐dependent functions at focal adhesions The EMBO Journal. ,vol. 33, pp. 356- 370 ,(2014) , 10.1002/EMBJ.201386399
Zheng Li, Huizi Lei, Min Luo, Yi Wang, Lei Dong, Yanni Ma, Changzheng Liu, Wei Song, Fang Wang, Junwu Zhang, Jianxiong Shen, Jia Yu, DNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer. Gastric Cancer. ,vol. 18, pp. 43- 54 ,(2015) , 10.1007/S10120-014-0340-8
T.M Weiner, R.J Craven, W.G Cance, Et Liu, Expression of focal adhesion kinase gene and invasive cancer The Lancet. ,vol. 342, pp. 1024- 1025 ,(1993) , 10.1016/0140-6736(93)92881-S
P. A. Randazzo, J. Andrade, K. Miura, M. T. Brown, Y.-Q. Long, S. Stauffer, P. Roller, J. A. Cooper, The Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 4011- 4016 ,(2000) , 10.1073/PNAS.070552297
Richard T Premont, Hye-Young Yoon, Paul A. Randazzo, Stacey Stauffer, Kerry Jacques, Beth Nealon, Differences between AGAP1, ASAP1 and Arf GAP1 in substrate recognition: interaction with the N-terminus of Arf1. Cellular Signalling. ,vol. 16, pp. 1033- 1044 ,(2004) , 10.1016/J.CELLSIG.2004.02.008