Vitamins and regulation of angiogenesis: [A, B1, B2, B3, B6, B9, B12, C, D, E, K]

摘要: Abstract Angiogenesis is one of the most important processes during wound healing, tissue regeneration, and tumor growth. Vitamins are micronutrients, which play great roles in many biochemical reactions inside cells cell pathways affecting various cellular functions. Here effects essential vitamins on angiogenesis overviewed. An electronic search was performed PubMed database via OVID from January 2000 to February 2017 using keywords regarding angiogenesis. Of 911 articles found our initial only 126 met inclusion criteria. Vitamin A, both 13-cis retinoid acid acyclic inhibit by suppressing VEGF, while all trans induces enhancing expression proangiogenic factors reducing pro-MMP2 activity. B1, Thiamine, simulates inducing proliferation human endothelial progenitor inhibiting apoptosis PKB/Akt-mediated potentiation. B2, Riboflavin, inhibits decreasing phosphorylation Src tyrosine 16, an activator residue kinase, a key player B3, Niacin, acts as a substance acting precursor NAD+, as well promoting function its receptor GPR109A. B6 micro vessel outgrowth cells. B9, Folic acid, cells, as activating Src/ERK2/NF-κB/p53 signaling pathways, resulting cycle arrest. B12, Cobalamin, pro-angiogenic production NO, prostaglandin E1, prostacyclin leading Furthermore, vitamin B12 reduces homocysteine levels plasma, significant anti-angiogenesis agent. C high concentrations alters metabolic activity cells; their ATP proliferation. Thus, has anti-angiogenic properties. D 1,25D3 form anti-proliferative arrest apoptosis. E, Tocopherols, exhibit inhibition tube formation through suppression that dependent activation PI3K/PDK/Akt signaling. K exhibits antiangiogenic protein S, vascular growth factor-receptor 2 (VEGFR2)-dependent vascularization VEGF induced migration According studies evaluated here, B, C, D, E pro- or activities based derivatives physiological settings. A shows anti- pro-angiogenesis B6, have properties B1 B3 proangiogenesis.