An Overview of Bilirubin Chemistry

摘要: “From gall disease, that is from the yellow jaundice cometh great evil; it of all disease most powerful, when there wax within a man, unmeasured humors; these are tokens; patient’s body becometh bitter and as good silk; under root his tongue be swart veins pernicious, urine yellow”(1). The pigment referred to in this vivid eleventh-century Anglo-Saxon description cirrhosis was first isolated crystalline form by Virchow 1847(2), named bilirubin Stadeler 1864(3). Its structure determined Siedel Fischer 1933(4) confirmed total synthesis Plieninger 1943(5) more recently et al(6). Much basic chemistry elucidated than two decades ago, principally school. And today, despite fact metabolic waste-product no practical utility other its diagnostic value, scientific interest continues unabated. In past three years alone has been mentioned over 1600 publications, about 400 specifically with some aspect or biochemistry molecule. areas which appear have received attention recent mechanism formation, conjugation excretion, nature conjugates, bilirubin-protein complexes, photochemistry bilirubin.