Astin C Production by the Endophytic Fungus Cyanodermella asteris in Planktonic and Immobilized Culture Conditions.

摘要: The fungal endophyte Cyanodermella asteris (C. asteris) has been recently isolated from the medicinal plant Aster tataricus (A. tataricus). This fungus produces astin C, a cyclic pentapeptide with anticancer and anti-inflammatory properties. production of this secondary metabolite is compared in immobilized planktonic conditions. For cultures, stainless steel packing immersed culture broth used as support. In these conditions, exclusively grows on packing, which provides considerable advantage for C recovery purification. C. metabolism different according to conditions terms substrate consumption rate, cell growth, production. Immobilized-cell cultures yield 30% increase production, associated 39% biomass. inoculum type spores rather than hyphae, pre-inoculation washing procedure sodium hydroxide, turns out be beneficial both development onto Finally, influence parameters such pH medium composition evaluated. With optimized further improved reaching five times higher final specific value reported extraction A. (0.89 mg g−1 0.16 respectively).