Iron Oxide Mesoporous Magnetic Nanostructures with High Surface Area for Enhanced and Selective Drug Delivery to Metastatic Cancer Cells.
作者： Kheireddine El-Boubbou , O. M. Lemine , Rizwan Ali , Alshaimaa Alhallaj , Mohamed Boudjelal
DOI: 10.3390/PHARMACEUTICS13040553
关键词:
摘要: This work reports the fabrication of iron oxide mesoporous magnetic nanostructures (IO-MMNs) via nano-replication method using acid-prepared spheres (APMS) as rigid silica host and (III) nitrate precursor. The obtained nanosized mesostructures were fully characterized by SEM, TEM, DLS, FTIR, XRD, VSM, nitrogen physisorption. IO-MMNs exhibited relatively high surface areas large pore volumes (SBET = 70–120 m2/g Vpore 0.25–0.45 cm3/g), small sizes (~300 nm), good crystallinity magnetization, excellent biocompatibility. With their intrinsic porosities, drug loading efficiencies (up to 70%) achieved release rates found be pH-dependent. Cytotoxicity, confocal microscopy, flow cytometry experiments against different types cancerous cells indicated that Dox-loaded reduced viability metastatic MCF-7 KAIMRC-1 breast well HT-29 colon cancer cells, with least uptake toxicity towards normal primary 4-fold enhancement). These results strongly suggest potential use promising agents for enhanced effective delivery in theranostics.
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