Ex-vivo generation of human red cells for transfusion.

摘要: PURPOSE OF REVIEW The present article reviews the recent data concerning generation of red blood cells from haematopoietic stem using laboratory culture and discusses potential for generating cultured in sufficient quantity use transfusion practice. RECENT FINDINGS Functional human reticulocytes have been generated adult peripheral without heterologous feeder their viability was demonstrated vivo. Human erythroid progenitor lines produced cord induced pluripotent cell (hiPSC) progenitors. SUMMARY Availability quantities required therapy would a major impact on healthcare provision worldwide. Recent studies provide cause optimism that this ambitious goal is achievable. made shown to survive Erythroid derived cells, suggesting large-scale differentiation will be possible. Significant problems remain. More efficient enucleation induction maturation an phenotype order exploit high proliferative capacity embryonic hiPSCs. Novel bioengineering solutions generate large required, context, synthetic three-dimensional scaffolds mimic bone marrow niche holds great promise future.