Biosynthesis of a ganoderic acid in Saccharomyces cerevisiae by expressing a cytochrome P450 gene from Ganoderma lucidum.

作者: Wen-Fang Wang , Han Xiao , Jian-Jiang Zhong

DOI: 10.1002/BIT.26583

关键词:

摘要: Ganoderic acid (GA), a triterpenoid from the traditional Chinese medicinal higher fungus Ganoderma lucidum, possesses antitumor and other significant pharmacological activities. …

参考文章(34)
Jian-Jiang Zhong, Jian-Hui Xiao, Secondary metabolites from higher fungi: discovery, bioactivity, and bioproduction. Advances in Biochemical Engineering \/ Biotechnology. ,vol. 113, pp. 79- 150 ,(2009) , 10.1007/10_2008_26
Yi-Ning Xu, Xiao-Xia Xia, Jian-Jiang Zhong, Induction of ganoderic acid biosynthesis by Mn2+ in static liquid cultivation of Ganoderma lucidum. Biotechnology and Bioengineering. ,vol. 111, pp. 2358- 2365 ,(2014) , 10.1002/BIT.25288
Sameh Soliman, Yi Tang, Natural and engineered production of taxadiene with taxadiene synthase. Biotechnology and Bioengineering. ,vol. 112, pp. 229- 235 ,(2015) , 10.1002/BIT.25468
M. Wang, D. L. Roberts, R. Paschke, T. M. Shea, B. S. S. Masters, J.-J. P. Kim, Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 94, pp. 8411- 8416 ,(1997) , 10.1073/PNAS.94.16.8411
C. J. Paddon, P. J. Westfall, D. J. Pitera, K. Benjamin, K. Fisher, D. McPhee, M. D. Leavell, A. Tai, A. Main, D. Eng, D. R. Polichuk, K. H. Teoh, D. W. Reed, T. Treynor, J. Lenihan, H. Jiang, M. Fleck, S. Bajad, G. Dang, D. Dengrove, D. Diola, G. Dorin, K. W. Ellens, S. Fickes, J. Galazzo, S. P. Gaucher, T. Geistlinger, R. Henry, M. Hepp, T. Horning, T. Iqbal, L. Kizer, B. Lieu, D. Melis, N. Moss, R. Regentin, S. Secrest, H. Tsuruta, R. Vazquez, L. F. Westblade, L. Xu, M. Yu, Y. Zhang, L. Zhao, J. Lievense, P. S. Covello, J. D. Keasling, K. K. Reiling, N. S. Renninger, J. D. Newman, High-level semi-synthetic production of the potent antimalarial artemisinin Nature. ,vol. 496, pp. 528- 532 ,(2013) , 10.1038/NATURE12051
Afrodite Krokida, Costas Delis, Katrin Geisler, Constantine Garagounis, Daniela Tsikou, Luis M. Peña-Rodríguez, Dimitra Katsarou, Ben Field, Anne E. Osbourn, Kalliope K. Papadopoulou, A metabolic gene cluster in Lotus japonicus discloses novel enzyme functions and products in triterpene biosynthesis. New Phytologist. ,vol. 200, pp. 675- 690 ,(2013) , 10.1111/NPH.12414
Jorge O. Toth, Bang Luu, Guy Ourisson, Les acides ganoderiques tàz : triterpenes cytotoxiques de Ganoderma lucidum (Polyporacée) Tetrahedron Letters. ,vol. 24, pp. 1081- 1084 ,(1983) , 10.1016/S0040-4039(00)81610-X
Jianqin Li, Jianhui Zhang, Haimei Chen, Xiangdong Chen, Jin Lan, Chang Liu, Complete Mitochondrial Genome of the Medicinal Mushroom Ganoderma lucidum PLoS ONE. ,vol. 8, pp. e72038- ,(2013) , 10.1371/JOURNAL.PONE.0072038
Tessa Moses, Jacob Pollier, Lorena Almagro, Dieter Buyst, Marc Van Montagu, María A Pedreño, José C Martins, Johan M Thevelein, Alain Goossens, None, Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16α hydroxylase from Bupleurum falcatum Proceedings of the National Academy of Sciences of the United States of America. ,vol. 111, pp. 1634- 1639 ,(2014) , 10.1073/PNAS.1323369111
Pingping Wang, Yongjun Wei, Yun Fan, Qunfang Liu, Wei Wei, Chengshuai Yang, Lei Zhang, Guoping Zhao, Jianmin Yue, Xing Yan, Zhihua Zhou, Production of bioactive ginsenosides Rh2 and Rg3 by metabolically engineered yeasts. Metabolic Engineering. ,vol. 29, pp. 97- 105 ,(2015) , 10.1016/J.YMBEN.2015.03.003