摘要: Post-translocational protein import into mitochondria requires that the be unfolded prior to import. Mapping mitochondrial-assisted unfolding pathway of a cargo and demonstrating it deviates from spontaneous have provided valuable insight energetics translocation process.
nature.com
sci-hub.se 参考文章(19)
C. Ungermann, B. Guiard, W. Neupert, D. M. Cyr, The delta psi- and Hsp70/MIM44-dependent reaction cycle driving early steps of protein import into mitochondria. The EMBO Journal. ,vol. 15, pp. 735- 744 ,(1996) , 10.1002/J.1460-2075.1996.TB00409.X
Marinus Pilon, Randy Schekman, Protein translocation: how Hsp70 pulls it off. Cell. ,vol. 97, pp. 679- 682 ,(1999) , 10.1016/S0092-8674(00)80780-1
Kerstin Hill, Kirstin Model, Michael T. Ryan, Klaus Dietmeier, Falk Martin, Richard Wagner, Nikolaus Pfanner, Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins Nature. ,vol. 395, pp. 516- 521 ,(1998) , 10.1038/26780
Andreas Matouschek, Shihai Huang, Kevin S. Ratliff, Michael P. Schwartz, Jonathan M. Spenner, Mitochondria unfold precursor proteins by unraveling them from their N-termini. Nature Structural & Molecular Biology. ,vol. 6, pp. 1132- 1138 ,(1999) , 10.1038/70073
Bernd Bukau, Arthur L Horwich, The Hsp70 and Hsp60 Chaperone Machines Cell. ,vol. 92, pp. 351- 366 ,(1998) , 10.1016/S0092-8674(00)80928-9
Kent E.S Matlack, Benjamin Misselwitz, Kathrin Plath, Tom A Rapoport, BiP Acts as a Molecular Ratchet during Posttranslational Transport of Prepro-α Factor across the ER Membrane Cell. ,vol. 97, pp. 553- 564 ,(1999) , 10.1016/S0092-8674(00)80767-9
W Voos, B D Gambill, B Guiard, N Pfanner, E A Craig, Presequence and mature part of preproteins strongly influence the dependence of mitochondrial protein import on heat shock protein 70 in the matrix. Journal of Cell Biology. ,vol. 123, pp. 119- 126 ,(1993) , 10.1083/JCB.123.1.119
Cindy Voisine, Elizabeth A Craig, Nicole Zufall, Oliver von Ahsen, Nikolaus Pfanner, Wolfgang Voos, The Protein Import Motor of Mitochondria: Unfolding and Trapping of Preproteins Are Distinct and Separable Functions of Matrix Hsp70 Cell. ,vol. 97, pp. 565- 574 ,(1999) , 10.1016/S0092-8674(00)80768-0
Benjamin S Glick, CAN HSP70 PROTEINS ACT AS FORCE-GENERATING MOTORS ? Cell. ,vol. 80, pp. 11- 14 ,(1995) , 10.1016/0092-8674(95)90444-1
Thomas J. Ahrens, Water storage in the mantle Nature. ,vol. 342, pp. 122- 123 ,(1989) , 10.1038/342122A0