Host–microbial co-evolution in periodontitis associated with Aggregatibacter actinomycetemcomitans infection

作者: Toshiyuki Nagasawa , Shintaro Shimizu , Satsuki Kato , Yuko Nakatsuka , Takashi Kado

DOI: 10.1016/J.JOB.2013.10.002

关键词:

摘要: Abstract Periodontitis is caused by bacterial biofilms composed of more than 800 species. Not all biofilm bacteria are equally pathogenic; Aggregatibacter actinomycetemcomitans recognized as one the most virulent periodontopathic bacteria. A. also associated with systemic diseases, including cardiovascular disease and brain abscesses. Molecular mimicry between human β2-glycoprotein I may be diseases such threatened preterm labor (TPL), birth (PB), Buerger's disease. Patients certain genetic neutrophil dysfunction disorders (e.g., Kostmann Papillon-Lefevre syndromes) suffer from severe periodontitis. These patients frequently infected , suggesting that an impaired immune system might relevant in pathogenesis -associated Virulence differs amongst clones. JP2 a highly pathogenic clone has deletion leukotoxin promoter, resulting production large amounts leukotoxin. Dissemination skewed to regions ethnic groups. not been reported East Asia, e.g., Japan, Korea, China. However, insertion sequence promoter was Japanese periodontitis patients. This evidence suggests host–microbial co-evolution exist periodontitis, elucidation its host enable molecular diagnosis treatment

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