An EXTrauterine environment for neonatal development: EXTENDING fetal physiology beyond the womb.

摘要: Extreme prematurity is a major cause of neonatal mortality and morbidity, remains an unsolved clinical challenge. The development artificial womb, extrauterine system recreating the intrauterine environment, would support ongoing growth organ maturation extreme preterm fetus have potential to substantially improve survival reduce morbidity. Previous efforts toward such demonstrated ability maintain isolated for short periods support, but failed achieve long-term stability required application. Here we describe our initial experiments demonstrating stable fetal lambs developmentally equivalent premature infant up four weeks with hemodynamics, growth, development. achievement physiologic in has fundamentally change management outcome infant.