The Expanding World of Tissue Engineering: The Building Blocks and New Applications of Tissue Engineered Constructs

摘要: The field of tissue engineering has been growing in the recent years as more products have made it to market and new uses for engineered tissues emerged, motivating many researchers engage this multidisciplinary research. Engineered are now not only considered end regenerative medicine, but also emerged enabling technologies other fields research ranging from drug discovery biorobotics. This widespread use necessitates a variety methodologies production constructs. In review, these methods together with their non-clinical applications will be described. First, we focus on novel materials used scaffolds; such recombinant proteins synthetic, self assembling polypeptides. advances modular area discussed. Then scaffold-free methods, based either cell sheets or aggregates Cell sources that provide improved control over behavior pathway biomimetic microenvironments directing differentiation Finally, summarize emerging constructs model discovery, cancer biorobotics applications.