Biomarkers in phase I–II chemoprevention trials: lessons from the NCI experience
作者： Eva Szabo
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摘要: Early phase clinical trials are an essential component of chemopreventive drug development to identify signals efficacy that can subsequently be explored definitively in III trials. Whereas I focus on safety and identification optimal dose schedule for cancer prevention, II intermediate endpoints variably related development. The United States National Cancer Institute supports a programme devoted early prevention experience, along with the benefits limitations range biomarker used these studies, reviewed here.
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