Perioperative antithrombotic therapy does not increase the incidence of early postoperative thromboembolic complications and bleeding in kidney transplantation - a retrospective study.

摘要: Perioperative antithrombotic therapy could play a role in preventing thromboembolic complications (TEC) after kidney transplantation (KTx), but little is known on postoperative bleeding risks. This retrospective analysis comprises 2000 single-organ KTx recipients transplanted between 2011-2016 the two largest transplant centers of Netherlands. TEC and events were scored ≤7 days post-KTx. Primary analyses for associations with incidence bleeding. Secondary other potential risk factors. Mean age was 55±14 years, 59% male 60% received living donor kidney. Twenty-one patients (1.1%) had TEC. Multiple arteries (OR 2.79 [1.15-6.79]) obesity 2.85 [1.19-6.82]) identified as factors Bleeding occurred 88 (4.4%) varied significantly different therapies (P=0.006). Cardiovascular disease 2.01 [1.18-3.42]), preemptive 2.23 [1.28-3.89]), heparin infusion 1.69 [1.00-2.85]) vitamin K antagonists 6.60 [2.95-14.77]) associated an increased risk. Intraoperative antiplatelet not These regimens appear to be safe possible prevention without increasing transplantation. article protected by copyright. All rights reserved.