Preventing warfarin-related bleeding
作者： Jeffrey James Glasheen
DOI: 10.1097/01.SMJ.0000149422.50817.85
关键词:
摘要: Warfarin is one of the most common anticoagulants in current use. It maintains a narrow therapeutic index resulting significant amount bleeding. Changes concomitant medication use and acute illnesses are causes overanticoagulation. Monitoring regimens based on patient characteristics intensity duration anticoagulant therapy, along with simple prediction rules, can reduce risk warfarin-related Supratherapeutic international normalized ratios usually best treated by holding dose and/or reducing weekly warfarin. Patients bleeding require more urgent warfarin reversal.
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sci-hub.st 参考文章(20)
Jon D. Horton, Bruce M. Bushwick, Warfarin therapy: evolving strategies in anticoagulation. American Family Physician. ,vol. 59, pp. 635- 646 ,(1999)
AlexanderG.G. Turpie, Jack Hirsh, John Gunstensen, Harvey Nelson, Michael Gent, RANDOMISED COMPARISON OF TWO INTENSITIES OF ORAL ANTICOAGULANT THERAPY AFTER TISSUE HEART VALVE REPLACEMENT The Lancet. ,vol. 331, pp. 1242- 1245 ,(1988) , 10.1016/S0140-6736(88)92070-3
Sabapathy Panneerselvam, Caroline Baglin, Wendy Lefort, Trevor Baglin, Analysis of risk factors for over-anticoagulation in patients receiving long-term warfarin British Journal of Haematology. ,vol. 103, pp. 422- 424 ,(1998) , 10.1046/J.1365-2141.1998.00988.X
C. Seth Landefeld, Miriam W. Rosenblatt, Lee Goldman, Bleeding in outpatients treated with warfarin: relation to the prothrombin time and important remediable lesions. The American Journal of Medicine. ,vol. 87, pp. 153- 159 ,(1989) , 10.1016/S0002-9343(89)80690-4
C. Seth Landefeld, Ohio Lee Goldman, Major bleeding in outpatients treated with warfarin: incidence and prediction by factors known at the start of outpatient therapy The American Journal of Medicine. ,vol. 87, pp. 144- 152 ,(1989) , 10.1016/S0002-9343(89)80689-8
Jack Ansell, Jack Hirsh, James Dalen, Henry Bussey, David Anderson, Leon Poller, Alan Jacobson, Daniel Deykin, David Matchar, Managing Oral Anticoagulant Therapy Chest. ,vol. 119, pp. 22- ,(2001) , 10.1378/CHEST.119.1_SUPPL.22S
Philip S Wells, Anne M Holbrook, N Renee Crowther, Jack Hirsh, Interactions of Warfarin with Drugs and Food Annals of Internal Medicine. ,vol. 121, pp. 676- 683 ,(1994) , 10.7326/0003-4819-121-9-199411010-00009
Henry I. Bussey, Managing excessive warfarin anticoagulation. Annals of Internal Medicine. ,vol. 135, pp. 460- 462 ,(2001) , 10.7326/0003-4819-135-6-200109180-00015
Elaine M. Hylek, Susan Regan, Alan S. Go, Robert A. Hughes, Daniel E. Singer, Steven J. Skates, Clinical predictors of prolonged delay in return of the international normalized ratio to within the therapeutic range after excessive anticoagulation with warfarin. Annals of Internal Medicine. ,vol. 135, pp. 393- 400 ,(2001) , 10.7326/0003-4819-135-6-200109180-00008
C.Seth Landefeld, Rebecca J. Beyth, Anticoagulant-related bleeding: Clinical epidemiology, prediction, and prevention The American Journal of Medicine. ,vol. 95, pp. 315- 328 ,(1993) , 10.1016/0002-9343(93)90285-W