Sirolimus-based immunosuppressive therapy in liver transplant recipient with tacrolimus-related chronic renal insufficiency.
作者： Y.J. Yang , D.Z. Chen , L.X. Li , J.T. Kou , R. Lang
DOI: 10.1016/J.TRANSPROCEED.2008.01.081
关键词:
摘要: Abstract Background While providing potent immunosuppression for liver transplant recipients, calcineurin inhibitors (CNI) exhibit nephrotoxicity as a major side effect. The purpose of this study was to evaluate the safety and efficacy conversion from CNI sirolimus (SRL) among recipients with CNI-induced chronic nephrotoxicity. Methods Between January 2004 June 2005, we performed in 16 after median period 8.5 months transplantation. indication CNI-related serum creatinine (sCr) value >132.6 umol/L. Renal function measured before SRL. Clinical laboratory data related clinical course patients were recorded investigate conversion. Results Sixteen converted SRL developing Their renal improved gradually levels sCr decreased significantly within first 30 days (164.1 ± 12.48 μmol/L 130.1 5.573 μmol/L), over next 60 (97.86 11.69 90.7 8.95 μmol/L) (P Conclusions is safe, effective replacement agent primary immunosuppressive therapy following withdrawal CNIs
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