Enriched environment modulates behavior, myelination and augments molecules governing the plasticity in the forebrain region of rats exposed to chronic immobilization stress.

摘要: Recently, several reports on chronic stress have shown that prolonged exposure to contributes psychological and neurological complications. However, the impact of stress-induced alterations in myelination remains to be unexplored. Therefore, in current study, rats were subjected immobilization (IS) followed by enriched environment (EE) behavioral, neurochemical changes pertaining neuronal survival pathway, addition, ultrastructural myelin forebrain (FB) region analyzed. Immobilization stress-exposed (4 h/day IS, for 28 days) exhibited increased anhedonia, anxiety, immobility, reduced social interaction, which could reflected levels corticosterone. In contrast, EE (4 h IS+2 h EE/day, was found minimize anhedonic state, supress depressive-like features, enhance social interaction also reduce The FB brain revealed IS group showed enhanced g-ratio indicating decreased thickness, while manifesting myelination. Further, study exposed NGF, TrkA, PI3K, AKT, ERK, CREB, MBP regions whereas preserve normal protein mRNA these molecules. results from this suggest exerts a positive improving stress.