Emerging Strategies for the Treatment of Tumor Stem Cells in Central Nervous System Malignancies
作者： Imad Saeed Khan , Moneeb Ehtesham
DOI: 10.1007/978-3-319-16537-0_9
关键词:
摘要: High-grade central nervous system (CNS) tumors are notorious for high rates of recurrence and poor outcomes. A small cohort tumor cells, dubbed stem cells (TSC), now being recognized as an important subset the that is resistant to chemotherapy radiotherapy account rates. Recent research developing modalities target TSCs specifically in a bid improve response whole. The methods employed include targeting TSC-specific pathways or receptors, TSC-sensitizing agents radiotherapy, immunotherapy, TSC-differentiating agents, viral therapy. This chapter provides overview strategies expected help develop new more effective treatments CNS tumors.
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