Salicylate Damage to the Gastric Mucosal Barrier

作者: Horace W. Davenport

DOI: 10.1056/NEJM196706082762308

关键词:

摘要: EVER since Reaumur, more than two centuries ago, discovered that gastric juice digests meat, men have asked: "Why doesn't the stomach digest itself?" There are answers to this question. One is, of course, sometimes does itself, with disastrous consequences. The other is mucosa contains a barrier prevents digestive from attacking wall stomach. A standard scientific method studying any system introduce perturbation and see what happens. Because salicylates — acetylsalicylic salicylic acids – destroy mucosal barrier, I used . . .

参考文章(12)
C. F. Code, J. A. Higgins, J. C. Moll, A. L. Orvis, J. F. Scholer, The influence of acid on the gastric absorption of water, sodium and potassium The Journal of Physiology. ,vol. 166, pp. 110- 119 ,(1963) , 10.1113/JPHYSIOL.1963.SP007093
FRANKLIN HOLLANDER, THE TWO-COMPONENT MUCOUS BARRIER A.M.A. Archives of Internal Medicine. ,vol. 93, pp. 107- 120 ,(1954) , 10.1001/ARCHINTE.1954.00240250117009
Horace W. Davenport, Stimulation of Gastric Motility by Acid Gastroenterology. ,vol. 52, pp. 198- 204 ,(1967) , 10.1016/S0016-5085(67)80007-6
Leonard R. Johnson, Bergein F. Overholt, Release of Histamine into Gastric Venous Blood Following Injury by Acetic or Salicylic Acid Gastroenterology. ,vol. 52, pp. 505- 509 ,(1967) , 10.1016/S0016-5085(67)80177-X
Horace W. Davenport, Hugh A. Warner, Charles F. Code, FUNCTIONAL SIGNIFICANCE OF GASTRIC MUCOSAL BARRIER TO SODIUM. Gastroenterology. ,vol. 47, pp. 142- 152 ,(1964) , 10.1016/S0016-5085(19)34760-2
Horace W. Davenport, Sodium and potassium in canine gastric mucosa and smooth muscle American Journal of Physiology-Legacy Content. ,vol. 205, pp. 413- 416 ,(1963) , 10.1152/AJPLEGACY.1963.205.3.413
Horace W. Davenport, Bennett J. Cohen, Max Bree, Virginia D. Davenport, DAMAGE TO THE GASTRIC MUCOSA: EFFECTS OF SALICYLATES AND STIMULATION. Gastroenterology. ,vol. 49, pp. 189- 196 ,(1965) , 10.1016/S0016-5085(19)34565-2