Patterns of neurocognitive impairment in first-episode bipolar disorder and schizophrenia.

摘要: Background Researching psychotic disorders in unison rather than as separate diagnostic groups is widely advocated, but the viability of such an approach requires careful consideration from a neurocognitive perspective. Aims To describe cognition people with bipolar disorder and schizophrenia to examine how known causes variability individual’s performance contribute to any observed diagnostic differences. Method Neurocognitive functioning ( n = 32), 46) healthy controls 67) was compared using analysis covariance on data Northern Ireland First Episode Psychosis Study. Results The were most impaired tests of memory, executive language. group performed significantly better response inhibition, verbal fluency callosal functioning. Between-group differences could be explained by greater proclivity individuals experience global cognitive impairment negative symptoms. Conclusions Particular impairments are common psychosis may prove useful endophenotypic markers. Considering degree individuals’ global cognitive critical when attempting understand patterns selective both within between these groups.