Mechanistic modeling of a capsule filling process.
作者： Peter Loidolt , Stefan Madlmeir , J.G. Khinast
DOI: 10.1016/J.IJPHARM.2017.08.125
关键词:
摘要: Filling a dosator nozzle moving into a powder bed was investigated using the Discrete Element Method (DEM). Various particle diameters and contact properties were modeled. The …
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sci-hub.se 参考文章(27)
M. Suzuki, T. Shinmura, K. Iimura, M. Hirota, Study of the Wall Effect on Particle Packing Structure Using X-ray Micro Computed Tomography Advanced Powder Technology. ,vol. 19, pp. 183- 195 ,(2008) , 10.1163/156855208X293817
RP Zou, AB Yu, None, The packing of spheres in a cylindrical container: the thickness effect Chemical Engineering Science. ,vol. 50, pp. 1504- 1507 ,(1995) , 10.1016/0009-2509(94)00483-8
P. A. Cundall, O. D. L. Strack, A discrete numerical model for granular assemblies Géotechnique. ,vol. 29, pp. 47- 65 ,(1979) , 10.1680/GEOT.1979.29.1.47
Brian E Jones, The filling of powders into two-piece hard capsules. International Journal of Pharmaceutics. ,vol. 227, pp. 5- 26 ,(2001) , 10.1016/S0378-5173(01)00781-5
Ammar Khawam, Modeling powder encapsulation in dosator-based machines: I. Theory International Journal of Pharmaceutics. ,vol. 421, pp. 203- 209 ,(2011) , 10.1016/J.IJPHARM.2011.10.021
R.J. Roberts, R.C. Rowe, P. York, The relationship between Young's modulus of elasticity of organic solids and their molecular structure Powder Technology. ,vol. 65, pp. 139- 146 ,(1991) , 10.1016/0032-5910(91)80176-J
Eva Faulhammer, Marlies Fink, Marcos Llusa, Simon M. Lawrence, Stefano Biserni, Vittorio Calzolari, Johannes G. Khinast, Low-dose capsule filling of inhalation products: Critical material attributes and process parameters International Journal of Pharmaceutics. ,vol. 473, pp. 617- 626 ,(2014) , 10.1016/J.IJPHARM.2014.07.050
Fridrun Podczeck, Simon Blackwell, Matthew Gold, J.Michael Newton, The filling of granules into hard gelatine capsules. International Journal of Pharmaceutics. ,vol. 188, pp. 59- 69 ,(1999) , 10.1016/S0378-5173(99)00208-2
I.G. Jolliffe, J.M. Newton, J.K. Walters, Theoretical considerations of the filling of pharmaceutical hard gelatin capsules Powder Technology. ,vol. 27, pp. 189- 195 ,(1980) , 10.1016/0032-5910(80)85021-2
Fridrun Podczeck, J.Michael Newton, Powder and capsule filling properties of lubricated granulated cellulose powder. European Journal of Pharmaceutics and Biopharmaceutics. ,vol. 50, pp. 373- 377 ,(2000) , 10.1016/S0939-6411(00)00100-4