Factors associated with improved survival following surgery for renal cell carcinoma spinal metastases.

摘要: OBJECTIVE Renal cell carcinoma (RCC) frequently metastasizes to the spine, causing pain or neurological dysfunction, and is often resistant standard therapies. Spinal surgery required, but may result in high morbidity rates. The authors sought identify prognostic factors determine clinical outcomes patients undergoing for RCC spinal metastases. METHODS searched records of who had undergone metastatic disease at a single institution during 12-year period retrieved data 30 with RCC. were retrospectively reviewed on preoperative conditions, treatment, survival. Statistical analyses (i.e., Kaplan-Meier survival analysis log-rank test univariate analysis) performed R version 2.15.2. RESULTS (23 men 7 women mean age 57.6 years [range 29-79 years]) total 40 surgeries indications included (70%) weakness (30%). Fourteen (47%) Instability Neoplastic Score (SINS) indicating indeterminate impending instability, 6 (20%) SINS denoting instability. median length postoperative estimated was 11.4 months. Younger (p = 0.001) control primary site 0.005), both significantly associated improved In contrast, visceral 0.002) osseous 0.009) metastases, nonambulatory status 0.001), major comorbidities 0.015) all decreased Postoperative Frankel grades same 78% patients. Major complications occurred 9 patients, there 3 deaths (10%) 30-day in-hospital period. Three en bloc resections performed. CONCLUSIONS Resection fixation provide relief stabilization metastases arising from RCC, surgical rates remain high. solitary good function, limited have longer benefit aggressive intervention.