Monte Carlo simulation of early molecular evolution in the RNA World.

摘要: The origin of life remains a highly speculative field, mainly due to the shortage our knowledge on prebiotic chemistry and basic understanding essence life. In this context, computer simulation is expected play an important role. For instance, scenario concerning genesis widely accepted RNA World blurry, though we have gathered some circumstantial evidence fragmented several supposed stages, including formation polynucleotides from nucleotide pool, emergence replicases (RNA molecules catalyzing their own replication), evolution replicases. It valuable simulate stages as continuous process evaluate plausibility supposition study rules involved. Here construct using Monte Carlo method. demonstrates that primordial may appear spread in pool provided they could recognize sequence complements catalytic targets, then evolve more efficient Apart its indication World, vivid "first replicative molecules" subsequent impressive help get insight into "how self-replication Darwinian evolution, two key features life, emerge non-life background?" thus improve "what life" when studying origins