p53-Dependent suppression of genome instability in germ cells.
作者： Shinji Otozai , Tomoko Ishikawa-Fujiwara , Shoji Oda , Yasuhiro Kamei , Haruko Ryo
DOI: 10.1016/J.MRFMMM.2013.12.004
关键词:
摘要: Radiation increases mutation frequencies at tandem repeat loci. Germline mutations in γ-ray-irradiated medaka fish (Oryzias latipes) were studied, focusing on the microsatellite Mismatch-repair genes suppress by directly removing altered sequences nucleotide level, whereas p53 gene suppresses genetic alterations eliminating damaged cells. The contribution of these two defense mechanisms to radiation-induced instability was addressed. spontaneous frequency significantly higher msh2(-/-) males than wild-type fish, there no difference between and fish. By contrast, irradiated p53(-/-) exhibited markedly increased frequencies, their same as that In spermatogonia testis, radiation induced a high level apoptosis both but negligible levels results demonstrate msh2 protect genome integrity against different pathways: direct removal mismatches elimination
sci-hub.se 参考文章(58)
Olga Kovalchuk, Yuri E. Dubrova, Andrey Arkhipov, Barbara Hohn, Igor Kovalchuk, Wheat mutation rate after Chernobyl web science. ,vol. 407, pp. 583- 584 ,(2000) , 10.1038/35036692
K Hiyama, M Kodaira, K Toyama, C Satoh, Lack of effects of atomic bomb radiation on genetic instability of tandem-repetitive elements in human germ cells. American Journal of Human Genetics. ,vol. 57, pp. 1275- 1283 ,(1995)
Hans Ellegren, Gabriella Lindgren, Craig R. Primmer, Anders Pape Møller, Fitness loss and germline mutations in barn swallows breeding in Chernobyl Nature. ,vol. 389, pp. 593- 596 ,(1997) , 10.1038/39303
Hans Ellegren, Microsatellite mutations in the germline:: implications for evolutionary inference Trends in Genetics. ,vol. 16, pp. 551- 558 ,(2000) , 10.1016/S0168-9525(00)02139-9
ALEC J. JEFFREYS, Highly variable minisatellites and DNA fingerprints. Biochemical Society Transactions. ,vol. 15, pp. 309- 317 ,(1987) , 10.1042/BST0150309
Gene Levinson, George A Gutman, Slipped-strand mispairing: a major mechanism for DNA sequence evolution. Molecular Biology and Evolution. ,vol. 4, pp. 203- 221 ,(1987) , 10.1093/OXFORDJOURNALS.MOLBEV.A040442
Arnold J. Levine, Moshe Oren, The first 30 years of p53: growing ever more complex Nature Reviews Cancer. ,vol. 9, pp. 749- 758 ,(2009) , 10.1038/NRC2723
Ruth C. Barber, Laurent Miccoli, Paul P.W. van Buul, Karen L.-A. Burr, Annemarie van Duyn-Goedhart, Jaime F. Angulo, Yuri E. Dubrova, Germline mutation rates at tandem repeat loci in DNA-repair deficient mice. Mutation Research. ,vol. 554, pp. 287- 295 ,(2004) , 10.1016/J.MRFMMM.2004.05.003
Yoshiyuki Sakuraba, Hideki Sezutsu, K. Ryo Takahasi, Keiko Tsuchihashi, Rie Ichikawa, Naomi Fujimoto, Satoko Kaneko, Yuji Nakai, Masashi Uchiyama, Noriko Goda, Rika Motoi, Ami Ikeda, Yuko Karashima, Maki Inoue, Hideki Kaneda, Hiroshi Masuya, Osamu Minowa, Hideki Noguchi, Atsushi Toyoda, Yoshiyuki Sakaki, Shigeharu Wakana, Tetsuo Noda, Toshihiko Shiroishi, Yoichi Gondo, Molecular characterization of ENU mouse mutagenesis and archives. Biochemical and Biophysical Research Communications. ,vol. 336, pp. 609- 616 ,(2005) , 10.1016/J.BBRC.2005.08.134
Yuri E. Dubrova, Olga G. Ploshchanskaya, Olga S. Kozionova, Alexander V. Akleyev, Minisatellite germline mutation rate in the Techa River population. Mutation Research. ,vol. 602, pp. 74- 82 ,(2006) , 10.1016/J.MRFMMM.2006.08.001