Quantitative chest CT for subtyping chronic lung allograft dysfunction and its association with survival.
作者： Miho Horie , Pascal Salazar , Tomohito Saito , Matthew Binnie , Kristy Brock
DOI: 10.1111/CTR.13233
关键词:
摘要: Chronic lung allograft dysfunction (CLAD) is a major cause of mortality in transplant recipients. CLAD can be sub-divided into at least 2 subtypes with distinct risk characteristics: restrictive syndrome (RAS), which demonstrates increased overall computed tomography (CT) density contrast bronchiolitis obliterans (BOS), reduced CT density. This study aimed to evaluate reader-independent quantitative metric (QDM) derived from histograms associate survival. A retrospective evaluated scans corresponding onset using pulmonary function tests 74 patients (23 RAS, 51 BOS). Two different QDM values (QDM1 and QDM2) were calculated histograms. Calculation QDM1 includes the extreme edges histogram. QDM2 central region Kaplan-Meier analysis Cox regression used for prognosis. Higher significantly associated decreased The hazard ratio death was 3.2 times higher 75th percentile compared 25th univariate model. may patient
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