The Epididymis as a Target for Male Contraception

摘要: The advantage of post-testicular contraception lies in its rapid onset infertility, reversible nature and the fast return fertility once therapy is withdrawn. Natural infertility stemming from epididymal dysfunction observed s everal do mestic species some transgenic mice indicates that this no idle quest. Although malfunction has been suggested to account for 20 % cases human necrozoospermia (Nduwayo et al., 1995), it difficult prove, so there are few male unequivocally caused by (De Kretser 1998). Most reports on contraceptives males describe animal experiments, but they based physiological principals sperm transport, maturation storage applicable man. actual or predicted action compounds with contraceptive potential will be reviewed here, avoid undue length overlap recent updates research area (Cooper Yeung, 1999a,Cooper 1999b), reference Cooper (1992) recommended older literature. Studies attempting induce animals can categorized processes interrupt into those which alter modify luminal fluid composition attack spermatozoa; discussed under these main headings.