A Gene for Recessive Nonsyndromic Sensorineural Deafness (DFNB18) Maps to the Chromosomal Region 11p14–p15.1 Containing the Usher Syndrome Type 1C Gene
作者： Pawan K. Jain , Anil K. Lalwani , Xiaoyan C. Li , Teresa L. Singleton , Tenesha N. Smith
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摘要: Autosomal recessive nonsyndromic sensorineural deafness segregating in a large consanguineous Indian family was mapped to chromosome 11p14–p15.1 defining new locus,DFNB18.A maximum lod score of 4.4 at θ = 0 obtained for the polymorphic microsatellite markerD11S1888.Haplotype analysis localizes this gene between markersD11S1307andD11S2368,which is approximately 1.6 cM and encompasses region Usher syndrome type 1C (USH1C). We postulate thatDFNB18andUSH1Care allelic variants same gene.
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