A comparative evaluation of the diagnostic value of anti-cyclic citrullinated peptide and rheumatoid factor in rheumatoid arthritis

摘要: BACKGROUND Despite its unsatisfactory specificity, rheumatoid factor (RF) is the only serologic marker included in diagnostic criteria of American College Rheumatology (ACR) for arthritis. Recently, value anti-cyclic citrullinated peptide (CCP) antibodies has been emphasized arthritis (RA) due to high specificity. To evaluate second generation anti-CCP as a marker, we evaluated test 163 individuals. METHODS The study population was divided into following four groups: RA group (n=18), other disease with arthritic symptoms (n=44), without (n=45), and healthy (n=56). Anti-CCP measured by an ELISA analyzer (Coda, Bio-Rad, USA) Immunoscan (Euro-Diagnostica, Malmo, Sweden) RF automated chemistry (Toshiba, Japan) RF-LATEX X1 (Denka Seiken, Japan). RESULTS sensitivity 72.2% 100%, respectively, respective figures specificity were 96.6% 73%. On each ROC curve, area under curve 0.867 0.959 RF. In groups, most false positive cases found patients hyperlipidemia or HBV carriage. However, not detected any these two conditions. False rates three control groups 34.1% symptoms, 48.9% 3.6% group. 6.8%, 2.2%, 1.8%. CONCLUSIONS higher than that discriminating from diseases, especially With can play additive role establishing diagnosis positivity.