Cutting Edge: Instructive Role of Peripheral Tissue Cells in the Imprinting of T Cell Homing Receptor Patterns
作者： Fanny Edele , Rosalie Molenaar , Dominique Gütle , Jan C. Dudda , Thilo Jakob
DOI: 10.4049/JIMMUNOL.181.6.3745
关键词:
摘要: Tissue-specific homing of effector and memory T cells to skin small intestine requires the imprinting specific combinations adhesion molecules chemokine receptors by dendritic in draining lymph nodes. In this study, we demonstrate that CD8(+) activated Ag-pulsed bone marrow-derived were induced express alpha(4)beta(7) integrin receptor CCR9 coculture with intestinal epithelial cells. contrast, dermal fibroblasts skin-homing E-selectin ligand was induced. Interestingly, gut on anti-CD3/anti-CD28 stimulated soluble factors produced Retinoic acid identified as a crucial factor. These findings show peripheral tissue directly produce suggest can acquire their potential already origin.
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jimmunol.org参考文章(35)
Jan C. Dudda, Jan C. Simon, Stefan Martin, Dendritic Cell Immunization Route Determines CD8 + T Cell Trafficking to Inflamed Skin: Role for Tissue Microenvironment and Dendritic Cells in Establishment of T Cell-Homing Subsets Journal of Immunology. ,vol. 172, pp. 857- 863 ,(2004) , 10.4049/JIMMUNOL.172.2.857
Francis W. Luscinskas, Geoffrey Scott Kansas, Amy J. Wagers, Yaw Chyn Lim, Andrew H. Lichtman, Lori Henault, Expression of Functional Selectin Ligands on Th Cells Is Differentially Regulated by IL-12 and IL-4 Journal of Immunology. ,vol. 162, pp. 3193- 3201 ,(1999)
Leslie Saurer, Kenneth C. McCullough, Artur Summerfield, In Vitro Induction of Mucosa-Type Dendritic Cells by All-Trans Retinoic Acid Journal of Immunology. ,vol. 179, pp. 3504- 3514 ,(2007) , 10.4049/JIMMUNOL.179.6.3504
M. Bens, A. Bogdanova, F. Cluzeaud, L. Miquerol, S. Kerneis, J. P. Kraehenbuhl, A. Kahn, E. Pringault, A. Vandewalle, Transimmortalized mouse intestinal cells (m-ICc12) that maintain a crypt phenotype American Journal of Physiology-cell Physiology. ,vol. 270, ,(1996) , 10.1152/AJPCELL.1996.270.6.C1666
Jan C. Dudda, Annalisa Lembo, Eva Bachtanian, Jochen Huehn, Christiane Siewert, Alf Hamann, Elisabeth Kremmer, Reinhold Förster, Stefan F. Martin, Dendritic cells govern induction and reprogramming of polarized tissue‐selective homing receptor patterns of T cells: important roles for soluble factors and tissue microenvironments European Journal of Immunology. ,vol. 35, pp. 1056- 1065 ,(2005) , 10.1002/EJI.200425817
Minghui Zhang, Hua Tang, Zhenhong Guo, Huazhang An, Xuejun Zhu, Wengang Song, Jun Guo, Xin Huang, Taoyong Chen, Jianli Wang, Xuetao Cao, Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells Nature Immunology. ,vol. 5, pp. 1124- 1133 ,(2004) , 10.1038/NI1130
Bengt Johansson-Lindbom, Marcus Svensson, Marc-André Wurbel, Bernard Malissen, Gabriel Márquez, William Agace, Selective Generation of Gut Tropic T Cells in Gut-associated Lymphoid Tissue (GALT) Requirement for GALT Dendritic Cells and Adjuvant Journal of Experimental Medicine. ,vol. 198, pp. 963- 969 ,(2003) , 10.1084/JEM.20031244
David J. Mangelsdorf, Ronald M. Evans, The RXR heterodimers and orphan receptors Cell. ,vol. 83, pp. 841- 850 ,(1995) , 10.1016/0092-8674(95)90200-7
Hekla Sigmundsdottir, Junliang Pan, Gudrun F Debes, Carsten Alt, Aida Habtezion, Dulce Soler, Eugene C Butcher, DCs Metabolize Sunlight-Induced Vitamin D3 to 'Program' T Cell Attraction to the Epidermal Chemokine CCL27 Nature Immunology. ,vol. 8, pp. 285- 293 ,(2007) , 10.1038/NI1433
J. Rodrigo Mora, Maria Rosa Bono, N. Manjunath, Wolfgang Weninger, Lois L. Cavanagh, Mario Rosemblatt, Ulrich H. von Andrian, Selective imprinting of gut-homing T cells by Peyer's patch dendritic cells Nature. ,vol. 424, pp. 88- 93 ,(2003) , 10.1038/NATURE01726