Unrelated umbilical cord blood transplantation in adult patients.

摘要: Abstract Since January 1996, we have administered myeloablative therapy followed by infusion of unrelated umbilical cord blood cells in 57 adult patients with high-risk disease. The median age was 31 years (range, 18–58 years), and the weight 70 kg 46–110 kg). Two were treated for genetic disorders 55 advanced hematologic malignancies. preparative regimens total body irradiation or busulfan based, both antithymocyte globulin. HLA matching between donor recipient 3 6 patients, 4 44 5 8 2 patients. nucleated cell dose 1.50 × 107/kg 0.54–2.78 107/kg), CD34+ 1.37 105/kg 0.02–12.45 105/kg). All received granulocyte colony-stimulating factor after transplantation until neutrophil recovery. Graft-versus-host disease prophylaxis consisted cyclosporine steroids. number days to an absolute count 500/μL 26 12–55 days). time untransfused platelet >20 000/μL 84 35–167 Seventeen developed grade II IV acute GVHD. survival entire group 91 10–2251 Eleven alive at a follow-up 1670 67–2251 days), 1 autologous recovery relapsed lymphoma. actuarial projected 3-year is 19%. Infection primary cause death. These results suggest that viable option should be explored earlier-stage