The Earliest Stage of Cognitive Impairment in Transition From Normal Aging to Alzheimer Disease Is Marked By Prominent RNA Oxidation in Vulnerable Neurons
作者： Akihiko Nunomura , Toshio Tamaoki , Nobutaka Motohashi , Masao Nakamura , Daniel W. McKeel
DOI: 10.1097/NEN.0B013E318248E614
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摘要: … Moreover, ribosomal RNA molecules are located closely to mitochondria, a major source of free radicals (3). We have focused on RNA oxidation and, for the first time, reported RNA …
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L. A. Sternberger, N. H. Sternberger, Principles of Immunocytochemistry Immunocytochemistry in Tumor Diagnosis. pp. 12- 20 ,(1985) , 10.1007/978-1-4613-2615-1_2
Akihiko Nunomura, George Perry, Miguel A. Pappolla, Robert P. Friedland, Keisuke Hirai, Shigeru Chiba, Mark A. Smith, Neuronal Oxidative Stress Precedes Amyloid-β Deposition in Down Syndrome Journal of Neuropathology & Experimental Neurology. ,vol. 59, pp. 1011- 1017 ,(2000) , 10.1093/JNEN/59.11.1011
Patrizia Mecocci, Oxidative stress in mild cognitive impairment and Alzheimer disease: a continuum. Journal of Alzheimer's Disease. ,vol. 6, pp. 159- 163 ,(2004) , 10.3233/JAD-2004-6207
Christopher D. Aluise, Renã A.S. Robinson, Jian Cai, William M. Pierce, William R. Markesbery, D. Allan Butterfield, Redox Proteomics Analysis of Brains from Subjects with Amnestic Mild Cognitive Impairment Compared to Brains from Subjects with Preclinical Alzheimer's Disease: Insights into Memory Loss in MCI Journal of Alzheimer's Disease. ,vol. 23, pp. 257- 269 ,(2011) , 10.3233/JAD-2010-101083
Akihiko Nunomura, George Perry, Gjumrakch Aliev, Keisuke Hirai, Atsushi Takeda, Elizabeth K. Balraj, Paul K. Jones, Hossein Ghanbari, Takafumi Wataya, Shun Shimohama, Shigeru Chiba, Craig S. Atwood, Robert B. Petersen, Mark A. Smith, Oxidative damage is the earliest event in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. ,vol. 60, pp. 759- 767 ,(2001) , 10.1093/JNEN/60.8.759
G. G. Fillenbaum, A. Heyman, Consortium to Establish a Registry for Alzheimer's Disease (CERAD) Neurology. ,vol. 44, pp. 228- 228 ,(2002) , 10.1002/0470846410.CH42(III)
Xiu Shan, Hirofumi Tashiro, Chien-liang Glenn Lin, The Identification and Characterization of Oxidized RNAs in Alzheimer's Disease The Journal of Neuroscience. ,vol. 23, pp. 4913- 4921 ,(2003) , 10.1523/JNEUROSCI.23-12-04913.2003
Akihiko Nunomura, George Perry, Miguel A. Pappolla, Ramon Wade, Keisuke Hirai, Shigeru Chiba, Mark A. Smith, RNA Oxidation Is a Prominent Feature of Vulnerable Neurons in Alzheimer’s Disease The Journal of Neuroscience. ,vol. 19, pp. 1959- 1964 ,(1999) , 10.1523/JNEUROSCI.19-06-01959.1999
Qunxing Ding, William R Markesbery, Qinghua Chen, Feng Li, Jeffrey N Keller, None, Ribosome Dysfunction Is an Early Event in Alzheimer's Disease The Journal of Neuroscience. ,vol. 25, pp. 9171- 9175 ,(2005) , 10.1523/JNEUROSCI.3040-05.2005
Akihiko Nunomura, Shigeru Chiba, Kenji Kosaka, Atsushi Takeda, Rudy J. Castellani, Mark A. Smith, George Perry, Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies. Neuroreport. ,vol. 13, pp. 2035- 2039 ,(2002) , 10.1097/00001756-200211150-00009