Dexamethasone for prevention of respiratory distress syndrome: multiple perinatal factors.

摘要: Antepartum dexamethasone administration was associated with a significant lowering of the incidence respiratory distress syndrome (RDS) and marked reduction early neonatal mortality in premature infants. Dexamethasone had its greatest effect infants delivered between 28 32 weeks' gestation (P < .001), difference still up to 34 .05). Although more patients intact membranes, it also effective those prolonged rupture membranes. Membrane condition before delivery unrelated RDS. The effectiveness analyzed respect infant at delivery, mode multiple births. As compared controls, most singletons, vaginally, high Apgar scores. not twins, breech deliveries, cesarean section or low effects appear be modified by intrauterine asphyxia. therapy cannot substituted for optimal conditions premature.