Tobacco-Specific Nitrosamines in Electronic Cigarettes: Comparison between Liquid and Aerosol Levels.

摘要: Introduction: Although electronic cigarette (EC) liquids contain low levels of tobacco-specific nitrosamines (TSNAs), studies evaluating the emitted to aerosol are scarce. The purpose this study was compare TSNAs between and generated aerosol. Methods: Three EC were obtained from market. An additional (spiked) sample prepared by adding known amounts standard solutions one liquids. N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT), N-nitrosoanabasine (NAB) 4-(methylnitrosamino)1-(3-pyridyl)-1-butanone (NNK) measured. 100-puff sets each liquid trapped in filter pads subsequently analyzed for presence TSNAs. expected (calculated based on consumption) compared with measured Results: Only NAB found at trace two commercial (1.2 2.3 ng/g), while third contained 1.5 ng/g 7.7 NNN. resulted 336–515 mg consumption, no being detected spiked 42.0–53.9 All statistically similar amounts. A significant correlation (r = 0.83, p < 0.001). Conclusion: findings show that exposure users can be accurately assessed present liquid, without need analyze